Is Pain After Using Trimix Normal? Here’s What You Should Know

As men age, they may begin to experience issues with sexual function. This can be a frustrating and often embarrassing problem that affects their intimacy and overall quality of life. As a result, many men turn to Trimix as a way to support sexual function. However, since Trimix is administered via injection, you may be wondering if it’s normal to experience pain after using Trimix. The following sections include some background information about Trimix, dosing guidance, and information on what to expect after injection.

An Overview Of Trimix Injections

Trimix injections are a mix of different medications, namely alprostadil, papaverine, and phentolamine. Alprostadil is commonly used for treating erectile dysfunction (and is an FDA-approved ingredient for ED), while papaverine and phentolamine work together to increase blood flow to the penis. By injecting Trimix directly into the penis, the compounded medication can help support sexual health.

Things To Remember Before Administering The Injection

While Trimix injections can help to support healthy sexual function, it is important to remember that they are prescription medications and should only be used as directed by a healthcare provider. Before administering the injection, there are several things you should keep in mind to ensure your safety and maximize the potential benefits of Trimix injections.

Proper Dosage

You need to use the correct dosage of Trimix injections to ensure the medication is both safe and effective. Your doctor should be able to determine the appropriate dosage based on your needs, considering factors such as age, weight, among others. Using a dose that is too small may not produce the desired results while using a dose that is too high can lead to potential side effects. At Universal Compounding Pharmacy (UCP), we compound Trimix into five different strengths to accommodate varying dosage requirements.

Proper Injection Technique

Improper injection technique can lead to pain and discomfort after using Trimix. You should carefully follow your healthcare provider’s (or pharmacist’s) instructions on how to inject the medication properly. This includes choosing the right injection site, inserting the needle correctly, and administering the medication slowly. You should also alternate injection sites to prevent tissue damage and scarring over time.

Proper Storage And Handling

Trimix needs to be stored properly to maintain its potency and effectiveness. As soon you receive your medication, you should store it in the refrigerator and only remove it when you are ready to use it. Trimix must be stored in an environment from 36°F to 46°F (2°C to 8°C) to prevent the medication from breaking down. It should also be kept out of reach of children and pets.

Additionally, Trimix should always be handled with clean hands and sterile equipment to prevent contamination. If the solution is contaminated or discolored, it should not be used. Not only can it affect the effectiveness of the medication, but it can also cause irritation following an injection.

Is It Common To Feel Pain After Injecting Trimix?

As with any medication, there is a risk of experiencing side effects. Because it requires direct injection into the penis, it is not uncommon for some patients to experience mild pain or discomfort. It’s estimated that around 30% of individuals who use Trimix may experience mild pain or discomfort following injection. Such discomfort should not be a cause for concern and typically resolves within a few minutes. 

However, it is essential to note that if the pain or discomfort persists for a prolonged period of time or becomes severe, you should seek medical attention immediately. This may be a sign of a more serious complication, such as an infection or improper injection technique.

How Long Will Post-Administration Pain Take To Subside?

In most cases, any post-injection pain or discomfort should subside within a few minutes after administering Trimix. If you experience prolonged pain or discomfort that does not go away, you should seek medical attention to rule out any potential complications.

Why Pain Occurs After The Injection

If you experience pain or discomfort after administering Trimix, several potential causes could exist. These can include the following:

Injection Site Irritation

Injection site irritation occurs when the medication irritates the skin or underlying tissue at the injection site. This can be due to using a dull needle, improper injection technique, or an allergic reaction to the medication itself. Sometimes, it may simply result from sensitive skin at the injection site. If you experience irritation, try using a different injection site and monitor for any improvement.


Bruising can occur when there is damage to the blood vessels at the injection site. This may happen if the needle is inserted too quickly or forcefully, causing small tears in the tissue. While bruising may be normal and should not affect future injections, it is important to monitor the severity of bruising and report any concerns to your healthcare provider.

Nerve Irritation

The injections may cause temporary irritation to nerves in the penis, leading to mild pain or discomfort. This can happen if the needle accidentally comes into contact with a nerve during injection. In most cases, this should subside within a few minutes as the medication takes effect.

Allergic Reaction

Although it is rare, some people may experience an allergic reaction to Trimix. Such reactions can cause symptoms such as swelling, redness, and pain at the injection site. If you experience an allergic reaction, seek medical attention immediately and discontinue using the medication.

Dose-Related Issues

As mentioned, using the correct dosage is crucial for safety and effectiveness when using Trimix. If you’re injecting a dose that’s too high, it can lead to pain and discomfort at the injection site. This can happen due to the medication’s potency or the volume of the solution injected. If you’re experiencing pain after administering Trimix, speak with your healthcare provider to determine if a dosage adjustment is necessary.

Factors To Look Out For That Should Prompt Medical Attention

While some mild pain or discomfort may be normal after administering Trimix, certain factors should prompt immediate medical attention. These include:

Prolonged Pain

If you experience pain or discomfort that is prolonged and does not subside within a few minutes, be sure to seek medical attention. This could be a sign of an underlying issue that requires treatment.

Penile Fibrosis Or Scarring

If you notice any changes in the appearance or texture of your penis after repeated injections, it could be a sign of penile fibrosis or scarring. This occurs when tissue damage from injection sites heals improperly, leading to hardening and scarring. If left untreated, fibrosis can lead to permanent damage and can affect sexual function. Seek medical attention if you notice any changes in your penile appearance or function.

Injection Site Issues

If you experience persistent pain, swelling, or redness at the injection site, it could be a sign of an infection caused by improper injection technique or contaminated equipment. Seek medical attention right away to prevent any potential complications.

Allergic Reactions

As mentioned earlier, if you experience any signs of an allergic reaction to Trimix, such as swelling or difficulty breathing, seek medical attention immediately. Discontinue the use of the medication and consult with your healthcare provider for alternative treatment options.

Ways To Lessen Post-Injection Pain

An easy way to alleviate post-injection pain and discomfort is to follow proper injection techniques. This includes using a new, sterile needle for each injection, injecting at the correct angle and depth, and rotating injection sites to prevent tissue damage. Other tips to lessen pain include:

1. Over-The-Counter Pain Relief

You can also take over-the-counter (OTC) pain medication, such as acetaminophen or ibuprofen, to alleviate any discomfort. However, be sure to stick to the recommended dosage when using pain medication. 

2. Warm Compress Or Bath

Another option is to use a warm compress or take a warm bath to help relax the muscles and ease any discomfort or pain. However, be sure not to use hot water as it can cause irritation at the injection site.

3. Changing The Injection Site At Regular Intervals

As mentioned earlier, rotating injection sites can help prevent tissue damage and reduce the chances of experiencing pain or discomfort. 

Consult A Physician To Obtain Professionally-Compounded Trimix

Trimix can be extremely beneficial when it comes to supporting sexual function. However, it’s essential to use the medication safely and effectively. By consulting a physician and obtaining professionally compounded Trimix, you can ensure that you receive the correct dosage and use the medication correctly.

Remember to always seek medical attention if you experience any concerning symptoms or reactions after using Trimix. By taking proper precautions and following recommended techniques, you can minimize post-injection pain and discomfort and safely enjoy the benefits of Trimix.

Discover personalized care and enhanced well-being with University Compounding Pharmacy’s Trimix Injections.